The box office is set to rebound in 2021 with everyone’s favorite R-rated superhero set to make a return. Ryan Reynolds is pulling on the spandex for Deadpool 3 and we have the odds on the Marvel characters set to make a cameo appearance.

Tom Holland’s Spiderman is the favorite to make an appearance with Reynolds in the Deadpool sequel. The last time that we saw Holland’s Spiderman, he had survived battling supervillains in Europe. With Tony Stark out of the picture, Reynold’s Deadpool could be the mentor to fill the void for Peter Parker.

Nicky Fury is another who would be at home in the Deadpool Universe. Samuel L. Jackson has battled snakes on a plane, so there would be no reason to think he wouldn’t be out of place in the Deadpool universe.

If you are a comic book geek familiar with the Marvel folklore, then a cameo from Thanos wouldn’t be a complete surprise. Tony Stark wiped out Thanos with a snap of his fingers, but a superhero recovery in a new film franchise wouldn’t be completely out of place. In the comic book version of the story, both Deadpool and Thanos are both in love with the same woman.