Odds courtesy of OddsShark.com

Two of the four top seeds in the 2017 NCAA Tournament will be in action on Thursday when betting action tips off in Buffalo and Salt Lake City.

And while the defending national champion Villanova Wildcats (31-3) await their opponent from Tuesday’s First Four, the Gonzaga Bulldogs (32-1) will try to prove their naysayers wrong and begin a run for their first-ever Final Four appearance.

The Bulldogs are listed as massive 22-point favorites as the No. 1 seed in the West against the 16th-seeded South Dakota State Jackrabbits (18-16), who won the Summit League in an upset. Gonzaga has gone 20-5-1 against the spread in its last 26 games while South Dakota State is 6-1 straight up so far this month with a longer current winning streak than its opponent at six.