An injury to middleweight champion Robert Whittaker has shaken up the betting odds for the main event at Saturday’s UFC 221 card in Perth, Australia. Instead of sitting as a solid underdog against Whittaker, challenger Luke Rockhold (16-3) is now a -160 favorite (bet $160 to win $100) versus No. 1 contender Yoel Romero (12-2).

Odds courtesy of OddsShark.com

Romero is listed as a +130 underdog (bet $100 to win $130) and coming off a unanimous-decision loss to Whittaker for the interim title on July 8 at UFC 213 in Las Vegas, snapping an eight-bout winning streak. He got the call to fight for the belt again when Whittaker did not properly treat a staph infection in his stomach and was forced to withdraw from his originally scheduled championship bout against Rockhold.

Whittaker had been promoted to middleweight champion when Georges St-Pierre gave up the belt after defeating Michael Bisping at UFC 217 last November 4. The winner of Romero-Rockhold will then take on Whittaker at a later date to unify the titles.