The Oklahoma Sooners have won the past two Big 12 titles in college football, and they are -110 favorites to take home their third in a row this year. The big question is, can another school from the conference prevent a three-peat?

Bettors would love to know the answer before the season kicks off, but there appears to be only three other top contenders to win the Big 12 in 2017 according to oddsmakers.

First of all, the Sooners obviously will be difficult to beat with the experience of winning the last two conference titles, going 17-1 in the Big 12 and 22-4 overall during that stretch. They also have one of the early Heisman Trophy favorites in senior quarterback Baker Mayfield, who has thrown 76 touchdowns and 15 interceptions at Oklahoma.

The Oklahoma State Cowboys (+300), Texas Longhorns (+500) and Kansas State Wildcats (+600) look to be the main challengers for the conference championship, although none of them have tied or won it since 2012. That year, the Wildcats tied the Sooners for the title with an 8-1 mark while the Cowboys and Longhorns tied for second at 5-4. Oklahoma State has also finished second in the Big 12 the past two years.