Can the second-ranked Penn State Nittany Lions upset the sixth-ranked Ohio State Buckeyes for the second year in a row and put themselves in position to earn their first College Football Playoff berth?

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That is the big question college football bettors are asking themselves as they prepare for this Saturday’s Big Ten showdown in Columbus, as Ohio State (6-1) sits as a 6-point home favorite over unbeaten Penn State (7-0).

Last season, the Nittany Lions turned an unlikely field-goal block into the game-winning touchdown to beat the Buckeyes 24-21 at home as 17.5-point underdogs. Ohio State is out to avenge that loss and prove a 31-16 home setback versus the 10th-ranked Oklahoma Sooners in its second game was a bit of a fluke.